Index
Fast chiral screening identification protocol
Click on items for more information
Case study 1
2-(2-Nitro-1-phenyl-ethyl)-malonic
acid diethyl ester
Case study 2
2-Acetylamino-4,4,4-trifluoro-butyr
ic acid
Case study 3
N-FMOC-2-Acetylamino-4,4,4-trifluoro-butyr
ic acid
Case study 4
1-(3,5-Dimethyl-pyrazol-1-yl)-propa
n-2-ol
Case study 5
cyclohexane-1,2-di amine derivative
Case study 6
N-Chroman-2-ylmethyl-benzamide
ChirBase Real Case Study
ChirBase will help you to plan a chiral screening protocol. In the following examples we have been able to select for each sample the best chiral separation method
Practical example 1
Sub-structure search in Chirbase using following query structure built in ISIS/Draw:
ChirBase search results : 26 hits
- 14 hits on CHIRALCEL OD chiral selector
- 7 hits on CHIRALPAK AD chiral selector
- 5 hits on CHIRALPAK AS chiral selector
Experimental results:
Chiral screening on these 3 columns allows separation on the following chiral selectors:
- CHIRALPAK AD (alpha = 2.79)
- CHIRALPAK AS (alpha = 1.12)