Practical example 5

Sub-structure search in Chirbase using following query structure built in ISIS/Draw:

ChirBase search results : 14 hits, two main columns

• 5 hits on CHIRALCEL OD chiral selector
• 3 hits on CHIRALPAK AD chiral selector

Experimental results:

Chiral screening on these columns allows separation on both chiral selectors:

• CHIRALCEL OD (alpha = 2.55)
• CHIRALPAK AD (alpha = 1.47)