The direct resolution of enantiomers by chromatography using chiral stationary phases (CSP) is today one of the most powerful techniques employed in pharmaceutical, agrochemical, asymmetric synthesis and related fields. In the last decade, there has been an exponential growth in the published literature. Since there are so many columns available to the analyst, the selection of the appropriate system (column and operating conditions) often remains difficult to find. In these courses, the different chromatographic technics (GC or LC) are reviewed, showing the application fields and the limits of the methods.
The courses deal the following topics :
Separation of enantiomers : Why? When? How? Static & Dynamic Stereochemistry
Chirality due to configuration or conformation sp3-sp3, sp2-sp3, sp2-sp2 systems, propellan Separation of Stereoisomers using classical methods
Crystallisation Enzymatic Applications and limits Separations by Chromatography
Review of the chromatographic techniques Separation by formation of stable diastereomeric isomers Direct resolution by chromatography Non-chiral phase: chiral additive, examples and applications Chiral phase: achiral mobile phases, bonded chiral stationary phases Synthetic chiral stationary phases, examples and applications Chiral stationary phase from natural products (proteins, sugars etc..), examples and applications Subcritical fluid chromatography, examples and applications Preparative applications of chromatography (moving beds) ChirBase Database (database for chiral separation by chromatography)
How to find a chromatographic method in ChirBase Strategies for searching in ChirBase
Training Lecturers :
Prof. Christian Roussel
Dr. Patrick Piras
For beginners, learn how to apply these techniques !
For others, improve and update your knowledge !
On-site one or two days Workshop in your company.
Our on-site workshop is tailored to the needs of your company (group the participants).
Four days training in our offices.