ChirBase Home Page

Search a molecular database of 190,000 chiral separations by HPLC, SFC, SMB...
80,000 chiral compounds
1780 chiral selectors
12,000 new chiral separations has been added this year
Large variety of topics from preclinical to production of chiral drugs accessible to a wide range of end-users from novices to experts
Read More

October 2012

Last update of ChirBase was delivered

Read more....

Testimonial

What users have written about ChirBase.....

Free download

Chiral Stationary Phase Database (using ISIS/Base from Accelrys/Symyx )

Events

Chirality 2013 in Shanghai, china

Past infos

ChirBase for ACD/Labs can be searched by structure, substructure, and method parameters with the ACD/ChromManager

..... Reviews

Read what users have written about ChirBase:

"The most advanced statistical and knowledge-based approach is the chiral separation database Chirbase"

Preparative chromatography of fine chemicals and pharmaceutical agents - H. Schmidt-Traub - 2005
-------------------------------------------------
"ChirBase, a database specializing in enantioseparation including SFC, can often aid in reducing the developing effort"

Advances in Chromatography, Volume 46 - Page 222 - Eli Grushka, Nelu Grinberg - 2007
-------------------------------------------------
"This database indicates that polysaccharide-based stationary phases are the most frequently utilized phases accounting for -40% of the separations. This database can be utilized as a starting point for method development"

HPLC for pharmaceutical scientists. 1. Edition - January 2007
Wiley-VCH - Kazakevich, Yuri V. / lobrutto, Rosario
-------------------------------------------------
"Finding the best chiral stationary phase/mobile phase combination can be time-consuming. Chirbase database specializing in chiral chromatographic separations including subFC/SFC, can often aid in reducing the development effort."

Journal of Chromatography A Volume 906, Issues 1-2, 12 January 2001, Pages 301-307 
Enantioseparations in super- and subcritical fluid chromatography
Gerald Terfloth
-------------------------------------------------
"Among several commercial chiral columns tested using the automated CHIRBASE system Chiralpak IB was found to be suitable for such resolution with a n-hexane/ethanol 98/2 (v/v) mobile phase"

Analytical Biochemistry, Volume 375, Issue 2, 15 April 2008, Pages 196-208
Novel chromatographic resolution of chiral diacylglycerols and analysis of the stereoselective hydrolysis of triacylglycerols by lipases
-------------------------------------------------
"The screening of CHIRBASE revealed that a few chiral rhenium complexes have already been separated by this method"

Inorg. Chem., 2006, 45 (25), pp 10230–10239
Synthesis and Vibrational Circular Dichroism of Enantiopure Chiral Oxorhenium(V) 
Complexes Containing the Hydrotris(1-pyrazolyl)borate Ligand
-------------------------------------------------
"For this application, it was demonstrated by internal studies and by using the Chirbase database that the Chiralpak AD type phase from Daicel was the most efficient candidate"

Preparative Enantioselective Chromatography (2007)
Editor(s):Geoffrey B. Cox 	
Case Study in Production-scale Multicolumn Continuous Chromatography Author: Michel Hamende 
-------------------------------------------------
"we attempt a less ambitions task of mapping the distribution of separation factors and resultant separation free-energy differences from the various CHIRBASE separations. We show that this seemingly naïve approach leads to unexpected and revealing information decrypting fundamental logic of chiral discrimination"

United States Patent Application 20060263824
Method for the use of information derived by the application of a probability law suitable for chiral selection and methods and systems employing same 
-------------------------------------------------
"However, we point out that while these computational tools are powerful when used properly, one still would like to use one's experience to determine how best to resolve enantiomers chromatographically. In this regard, then, we point out the enormous research effort by Roussel and Piras who created and maintain CHIRBASE, a graphical molecular database on the separation of enantiomers"

Journal of Chromatography A, 694 (1995) 15-37
Theoretical studies of type II-V chiral stationary phases
Kenny B. Lipkowitz
-------------------------------------------------
Cheminformatics Developments: History, Reviews and Current Research
The United Kingdom Chemical Database Service: CDS
Bob mcmeeking & Dave Fletcher

"ChirBase is a powerful Information System for Chiral Separations. ChirBase in common with all the ISIS databases that refer to the primary literature, has been enabled to 
use the LitLink system"
-------------------------------------------------
"A search of the database CHIRBASE revealed few instances of OL > 2 and these refer to one resolution on a metal complex phase and five on cyclodextrin"

Chirality
Volume 5 Issue 4, Pages 229 - 231(2004)
Direct resolution of enantiomers of basic imidazol-2-yl-substituted alcohols by gas chromatography on chirasil-val
-------------------------------------------------
"An inspection of the CHIRBASE database revealed about 350 enantioseparations of DNB derivatives obtained on DNB functionalized selectors"

Chirality, Volume 11 Issue 5-6, Pages 404 - 408
Diphenylethanediamine (DPEDA) as chiral selector IX: Self recognition of chiral selectors - efficient HPLC-separation of the enantiomers of 3,5,-dinitrobenzoylated diphenylalkaneamides on the immobilized analogue
Georg Uray, Karlheinz S. Niederreiter, Norbert M. Maier, Michaela M. Spitaler
-------------------------------------------------
"Any resolution of lorazepam, temazepam and lormetazepam was reported on homosubstituted carbamate cellulose and amylose CSPs as shown in Chirbase"

Journal of Chromatography A,Volume 786, Issue 1, 24 October 1997, Pages 13-21 
Regioselectivity carbamoylated polysaccharides for the separation of enantiomers in high-performance liquid chromatography 
-------------------------------------------------
"ChirBase, a database for chiral chromatography, was used to extract 51 pairs of enantiomers separated on the commercially available Whelk-O1 chiral stationary phase"

QSAR & Combinatorial Science, Volume 27 Issue 11-12, Pages 1326 - 1336 ( 2008)
Encoding Absolute Configurations with Chiral Enantiophore Descriptors. Application to the Order of Elution of Enantiomers in Liquid Chromatography"
Alberto Del Rio, Johann Gasteiger
-------------------------------------------------
"A search in the CHIRBASE database (Roussel, C.; Chirbase Project, Universite Aix-Marseille) resulted in the following citations for enantioseparation of DHPMs"

Tetrahedron: Asymmetry, Volume 8, Issue 12, 27 June 1997, Pages 2057-2067 
Separation of enantiomers of 4-aryldihydropyrimidines by direct enantioselective HPLC. A critical comparison of chiral stationary phases
-------------------------------------------------
"However, according to Chirbase database, no chiral HPLC resolution of trivalent phosphorus compound including a P−N bond, either free or as its borane adduct, has been reported in the literature"

J. Org. Chem., 2006, 71 (15), pp 5586–5593
Chromatographic Resolution, Solution and Crystal Phase Conformations, and Absolute Configuration of tert-Butyl(dimethylamino)phenylphosphine−Borane Complex
-------------------------------------------------
"Thus 3 types of CD phases with different polarity and ring size are selected with consideration of the Chirbase data bank"

Chirality, Volume 11 Issue 7, Pages 575 - 582 (1999)
Molecular parity violation via comets?
-------------------------------------------------
"The data was extracted and compiled from the ChirBase database (Marseille, France). 60, 000 entries of ChirBase working in the ISIS Base environment"

Separation & Purification Reviews, 2007 
Commercial Chiral Stationary Phases for the Separations of Clinical Racemic Drugs
G Felix, A Berthod
-------------------------------------------------
"Chirbase, which contains more than 110,000 references on different chiral chromatographic analyses, including approximately 26,000 CD-based separations in various chromatographic modes"

TrAC Trends in Analytical Chemistry
Volume 21, Issue 5, May 2002, Pages 379-388 
The role of cyclodextrins in chiral selective chromatography
-------------------------------------------------
"Here we report a comprehensive data examination of enantioseparation measurements for over 72,000 chiral selector-selectand pairs from the chiral selection compendium CHIRBASE"

Chirality, Volume 16 Issue 6, Pages 369 - 378
Probability rule for chiral recognition
-------------------------------------------------
"According to the Chirbase data bank, an appropriate CSP is available for essentially every racemic compound of a variety of different classes of compounds"

TrAC Trends in Analytical Chemistry
Volume 21, Issues 9-10, 10 September 2002, Pages 647-661
Volker Schurig, Chiral separations using gas chromatography 
-------------------------------------------------
"A survey of the chiral separation literature (Chirbase) seeking examples of metal complexes being separated on paper or cellulose, revealed that..."

Chem. Commun., 2001, 1078 - 1079,
Paper: a cheap yet effective chiral stationary phase for chromatographic resolution of metallo-supramolecular helicates 
-------------------------------------------------
"the results are compared (Table IV) to those obtained on Cyclobond-I (literature from Chirbase)"

Synthesis and chromatographic properties of HPLC chiral stationary phases based upon beta-cyclodextrins
Chromatographia, Volume 42, Numbers 9-10 / mai 1996
-------------------------------------------------
"This information repository was founded in 1993 by a group at the University Aix-Marseille III (France) to consolidate information on chiral separations and stationary phases"

In the Loop: Continuous Chromatography for Chiral Separations
Source: Pharmaceutical Technology
By: Douglas McCormick
-------------------------------------------------
"A methodology for the analytical separation of enantiomers of thiolesters and thiols is not described in the literature to the best of our knowledge on the basis of a literature search in the Chirbase molecular database"

Tetrahedron: Asymmetry
Volume 11, Issue 10, 2 June 2000, Pages 2125-2131 
Synthesis of (R)-4,4,4-trifluoro-2-mercaptobutyric acid
-------------------------------------------------
"Some experiments were carried out with trans-E3PG instead of linalool. In principle, the enantiomers of this molecule should be easily separated by β-cyclodextrin chromatography because the complexation constant of E3PG/β-cyclodextrin is higher than that of linalool/β-cyclodextrin (Chirbase)"

Journal of Membrane Science
Volume 237, Issues 1-2, 1 July 2004, Pages 9-14 
Enantioenrichment by pervaporation
-------------------------------------------------
"Author reviews the separation of racemic agrochemical compounds on commercial chiral stationary phases (CSPs) using the ChirBase database"

Overview of the separation of agrochemical enantiomers on commercial CSPs.
Journal of Liquid Chromatography & Related Technologies
-------------------------------------------------
"The enormous increase in recent years in number of groups working on chiral chromatography has led to a rapid and impressive accumulation of data in CHIRBASE"

Encyclopedia of Chemical Processing (2006)
Bingyun Li and Donald T. Haynie in "Chiral Drug Separation"